Tuesday, 10 December 2024

Comparing light scattering techniques for biologics development





SLS and DLS are robust investigative methods broadly utilized in the biopharmaceutical sector to characterize solution properties of colloidal drug delivery systems, macromolecules, nanoparticles, and viral vectors.
Static light scattering

SLS includes multi-angle light scattering and right-angle light scattering, techniques that calculate the precise values of the molecular weight, weight-average molecular weight, and the radius of gyration of target macromolecules.
Biopharmaceutical applications

SLS has many uses throughout the biopharmaceutical industry, including:Aggregation and degradation propensity disposition
Bioconjugate stability evaluation
Biopolymer characterization, e.g. bioconjugates, macromolecular complexes, peptides, proteins, RNA
Dynamic light scattering

DLS calculates temporal fluctuations in scattered light intensity to verify hydrodynamic radius size, polydispersity, and macromolecule stability in solution.
Biopharmaceutical applications

DLS has numerous use cases in the biopharmaceutical industry, including:Biologic formulation development
Colloidal stability analysis
Nanoparticle characterization
Quality control
Static vs. dynamic light scattering

SLS and DLS rely on the behavior of scattered light but offer corresponding data regarding investigative samples.

SLS verifies colloidal stability and offers precise values of molar mass, weight-average molecular weight, and radius of gyration of all biologic classes.

DLS is ideal for categorizing colloidal dispersions, macromolecules, and nanoparticles and calculates the polydispersity and hydrodynamic radius of macromolecules and macromolecular complexes in solution. It does not precisely verify absolute molecular weight or molecular weight distributions, only size.
SLS and DLS are corresponding methods

Combining SLS and DLS data offers a broader stability environment for target molecules and complexes. The two techniques are often employed together to better understand the biophysical and solution properties of all biologics.

The ARGEN platform utilizes SLS in a patented formation to enable faster biopharmaceutical development. ARGEN complements R&D instrument portfolios and swiftly evaluates biopolymer stability landscapes during early-phase formulation development.
Utilizing ARGEN to accelerate biopolymer formulation R&D

ARGEN is a patented SLS tool used in biopolymer research to overcome critical challenges. The platform is the equivalent of having multiple static light scattering devices in one benchtop instrument.

ARGEN provides accelerated in-situ, real-time stability monitoring, manufacturing stress modeling, shelf-life determination, and rapid parallel analysis, enabling more efficient formulation development.

Its features include:Real-time stability monitoring
Kinetics of Oligomeric State Transitions
Bioprocessing stress modeling
Parallel analysis
Low-temperature analysis
Versatility
Time reduction
Quality control and process development

These capabilities can create more stable and reliable biopolymer formulations, accelerating biopharma R&D efforts and reducing the time and resources spent on unsuccessful candidates.

#AmoPhysics, #NuclearPhysics,#AtomicNuclei#NuclearReactions#Radioactivity#NuclearFission#NuclearFusion#NuclearEnergy#NuclearPower#FusionResearch#FissionReactors#RadioactiveDecay#NuclearMedicine#NuclearAstrophysics, #ParticleAcceleration#NuclearSafety#NuclearEngineering#NuclearWeapons#RadiationProtection#NuclearPolicy#NuclearWasteManagement.


Visit: amo-physics-conferences.scifat.com/


Member Nomation link: https://x-i.me/amocon
Award Nomination link: https://x-i.me/amonom


For More Details : physics@scifat.com


Get Connected Here:
==================
Facebook : www.facebook.com/profile.php?id=100092029748922
Pinterest : in.pinterest.com/physicsresearch2000/
Youtube : www.youtube.com/channel/UCtntbI1RB0O0CFLpr575_fg
Instagram : www.instagram.com/amophysicsawards/

Monday, 9 December 2024


A novel antenna design can measure faint cosmological radio-frequency signals





The Universe is approximately 13.8 billion years old. Shortly after the Big Bang, it was hot and dense, preventing the existence of atoms and prompting matter formation in the form of electrons, protons, and light nuclei like helium and lithium.

Radiation also coexisted with matter, which we now observe as the Cosmic Microwave Background (CMB). The CMB’s distortions in its spectrum carry vital information about the early Universe.

One such distortion occurred during the Epoch of Recombination when the Universe cooled and expanded. This led to the transition of matter from a fully ionized plasma to neutral hydrogen and helium atoms. As this happened, photons were emitted in a process known as Cosmological Recombination Radiation (CRR), adding a distortion to the CMB spectrum.

It is a significant challenge to detect Cosmic Recombination Radiation (CRR), which is nine orders of magnitude fainter than the CMB. The CMB is measured at about 3 degrees Kelvin, equivalent to -270°C.

CRR’s detection would provide crucial confirmation of our understanding of the Universe’s thermal and ionization history. It would also offer a unique opportunity to measure the abundance of helium in the Universe before it started forming in the cores of stars. However, due to CRR’s extraordinarily faint and elusive nature, the scientific community faces the challenge of developing susceptible instruments to detect this radiation.

Scientists at the Raman Research Institute in Bangalore have developed a novel antenna design to perform sky measurements in the 2.5 – 4 Gigahertz (GHz) frequency range. This frequency range is considered optimal for detecting faint cosmic recombination radiation (CRR) signals, which have never been detected before. These elusive signals contain crucial information that could enhance our understanding of the Universe’s thermal and ionization history.

This unique ground-based broadband antenna can detect as faint as one part in 10,000.

Keerthipriya Sathish, lead author of the paper and Research Scientist at RRI, said, “For the sky measurements we plan to perform, the broadband antenna offered us the highest sensitivity compared to other antennas designed for the same bandwidth. The metric of being frequency-independent over the wideband and ensuring smooth frequency performance is unconventional, something only a custom design, such as ours, could achieve. An off-the-shelf wideband antenna won’t work.”

A fantail antenna has been proposed for detecting Cosmological Recombination Radiation (CRR) due to its unique design and stable frequency performance. This antenna features a dual-polarized dipole design with four arms, each shaped like a fantail. Its key advantage is that it maintains the same radiation pattern across frequencies, with only a +/- 1% variation in characteristics. This allows it to consistently target the same patch of the sky across its full operational bandwidth of 1.5 GHz (2.5 to 4 GHz), which is crucial for distinguishing spectral distortions from galactic foregrounds.

The antenna weighs 150 grams and measures 14 cm x 14 cm in a square box shape. It consists of a flat, low-loss dielectric substrate with the antenna etched in copper on top and an aluminum ground plate on the bottom. A thick foam layer, radio-transparent and housing the antenna’s connectors, sits between these plates, ensuring the antenna is lightweight yet robust for its purpose.

Mayuri Rao, faculty, RRI, said, “The antenna has a sensitivity of around 30 millikelvins (mK) across the 2.5-4 GHz frequency range, enabling it to detect tiny temperature variations in the sky. Even before scaling it to an array, this antenna will enable exciting first-science results once integrated with its custom receiver.”

“We plan to study a reported excess radiation in the sky from a previous experiment at 3.3 GHz, attributed to exotic physics, including Dark Matter annihilation. Such experiments with this antenna will help inform improvements in the antenna and experiment design to go all the way to the sensitivity needed for a CRR detection.”

The authors noted, “An antenna array will be deployed in radio-quiet locations, where there is minimal or no radio frequency interference. The design of this planar antenna is such that it is easily fabricated using methods similar to those used in Printed Circuit Board (PCB) printing. Thus, this design offers high machining accuracy and consistency during replication for multiple-element arrays, is portable and easily deployable.”

#AmoPhysics, #NuclearPhysics,#AtomicNuclei#NuclearReactions#Radioactivity#NuclearFission#NuclearFusion#NuclearEnergy#NuclearPower#FusionResearch#FissionReactors#RadioactiveDecay#NuclearMedicine#NuclearAstrophysics, #ParticleAcceleration#NuclearSafety#NuclearEngineering#NuclearWeapons#RadiationProtection#NuclearPolicy#NuclearWasteManagement.


Visit: amo-physics-conferences.scifat.com/


Member Nomation link: https://x-i.me/amocon
Award Nomination link: https://x-i.me/amonom


For More Details : physics@scifat.com


Get Connected Here:
==================
Facebook : www.facebook.com/profile.php?id=100092029748922
Pinterest : in.pinterest.com/physicsresearch2000/
Youtube : www.youtube.com/channel/UCtntbI1RB0O0CFLpr575_fg
Instagram : www.instagram.com/amophysicsawards/

Saturday, 7 December 2024

Alternate Timelines Can’t Help You, Quantum Physicists Say


The multiverse offers no escape from our reality—which might be a very good thing

By George Musser






As memes go, it wasn’t particularly viral. But for a couple of hours on the morning of November 6, the term “darkest timeline” trended in Google searches, and several physicists posted musings on social media about whether we were actually in it. All the probabilities expressed in opinion polls and prediction markets had collapsed into a single definite outcome, and history went from “what might be” to “that just happened.” The two sides in this hyperpolarized U.S. presidential election had agreed on practically nothing—save for their shared belief that its outcome would be a fateful choice between two diverging trajectories for our world.




That raises rather obvious (but perhaps pointless) questions: Could a “darkest timeline” (or any other “timeline,” for that matter) be real? Somewhere out there in the great beyond, might there be a parallel world in which Kamala Harris electorally triumphed instead?

It turns out that, outside of fostering escapist sociopolitical fantasies and putting a scientific gloss on the genre of counterfactual history, the notion of alternate timelines is in fact something physicists take very seriously. The concept most famously appears in quantum mechanics, which predicts a multiplicity of outcomes—cats that are both alive and dead and all that. If a particle of light—a photon—strikes a mirror that is only partially silvered, the particle can, in a sense, both pass through and reflect off that surface—two mutually exclusive outcomes, known in physics parlance as a superposition. Only one of those possibilities will manifest itself when an observation is made, but until then, the particle juggles both possibilities simultaneously. That’s what the mathematics says—and what experiments confirm. For instance, you can create a superposition and then uncreate it by directing the light onto a second partially silvered mirror. That wouldn’t be possible unless both possibilities remained in play. Although this feature is usually framed in terms of subatomic particles, it is thought to be ubiquitous across all scales in the universe.

What supports the idea that these timelines are real, and not just imaginative fictions, is that they can “interfere” with one another, either enhancing or diminishing the probability of their occurrence. That is, something that might have happened but doesn’t has a measurable effect on what does, as if the former reaches from the shadowy realm of the possible into the world of the actual.

Consider the bomb detector that physicists Avshalom Elitzur and Lev Vaidman proposed in 1993 and that has since been demonstrated (fortunately not with real bombs): Perform the experiment with the partially silvered mirror but place a light-sensitive bomb along one of the two paths the photon can take. This blockage prevents you from uncreating the superposition to restore the traveling photon to its original state. It does so even if the bomb never goes off, indicating that the photon never touched it. The mere possibility that the photon could strike the bomb affects what happens. In theory, you could use this principle—known as counterfactual definiteness—to take x-ray images of cells without subjecting them to damaging radiation. In an emerging subject known as counterfactual quantum computing, a computer outputs a value even if you never press the “run” button.

One way to think about counterfactual definiteness is known as the many-worlds interpretation. A photon striking a mirror causes the cosmic timeline to branch, creating one world in which the particle passes through the mirror and one in which it reflects off that surface. Each of us is stuck inside our world and therefore sees only one outcome at a time, but the other is still there, visible to an inhabitant of the alternate world. All such worlds, taken together, constitute a “multiverse.”

Whether they agree with the many-worlds interpretation or not, physicists and philosophers certainly love to argue about it. Some admire its elegance; others grouse about conceptual difficulties such as the slippery matter of what exactly constitutes a “world.” Quantum theory not only allows multiple worlds but also offers an infinity of ways to define them.

In all the debate over many worlds, though, the key insight of the idea’s originator, physicist Hugh Everett, is often forgotten. Everett developed his view in reaction to assumptions by other physicists that, because we can see only one of the possibilities of a superposition if a particle enters into that state, something must cause all the other possibilities to be discarded. In other words, some mechanism must collapse the superposition—perhaps the act of observation itself or some sporadic randomness inherent to the fabric of reality. Everett noticed a fallacy in this reasoning: it will always look as though the superposition has collapsed, even if it remains intact. The reason is that, in making our observation, we interact with the particle, and together we and it become a single combined system. Because the particle is in superposition, so are we. But we can’t tell. Everett’s fundamental point is this: We are part of the reality we seek to observe, yet no part can fully apprehend the whole, and thus our view is limited. Multiple timelines arise in the hidden recesses imposed by our very embedding within the universe.

Other branches of physics also conceive of existence as comprising forking timelines. Physicists consider counterfactuals when calculating the path of a particle; according to what they call the principle of least action, even a classical particle that exhibits no distinctively quantum effects susses out all the possibilities. In statistical physics, researchers study particles by the septillion by thinking in terms of “ensembles,” which are another kind of multiverse, spanning all the possible ways the particles can be arranged and evolve. Over time, the particles explore all possibilities open to them. We sense their machinations indirectly as the flow of heat and establishment of thermodynamic equilibrium. Going outside physics, evolutionary biologists also routinely talk about multiple timelines: If you reran the evolution of species, would things turn out the same?


All these scientific issues are rooted in a fundamental puzzle: What does it mean to be possible but not actual? Why is there something rather than something else? The physicist Paul Davies has called this the “puzzle of what exists.” It touches not just on esoteric ideas about branching timelines but also on aspects of everyday life such as causation. To say that something causes something else, there must be the possibility that the “something else” would never have happened in the first place. In astrobiologist Sara Imari Walker’s recent book on the physics of life, Life As No One Knows It, she noted that the entire observable universe doesn’t contain enough material to create every single possible small organic molecule, let alone big ones such as the DNA strands we know and love. For her, living things distinguish themselves by making molecules and other structures that are otherwise vanishingly unlikely to exist. Life blazes a path through the void of possibility space.

Perhaps some deep rule selects the actual reality from among the possible realities, but efforts to identify that principle have been serially dashed. It is hard to argue that ours is the best of all possible worlds. Nor, despite what the 19th-century philosopher Arthur Schopenhauer proclaimed, does it seem to be the worst—things could always get worse, Google searches for the “darkest timeline” notwithstanding. For many, such as philosopher David Lewis and cosmologist Max Tegmark, the most straightforward conclusion is that all possible realities exist.

The real question, then, is not whether there are other timelines; there certainly are. Rather it is why we see only one. Perhaps life or intelligence would not be possible if the branching were too evident to us. Physics is replete with such preconditions for our existence. For instance, if temporal flow did not have a directionality—an arrow of time—there could be no lasting change, no memories, no intelligence, no agency. Keeping other timelines hidden might be of similar importance. Quantum superposition may serve some specialized functions in our bodies, but otherwise it—along with any traces of alternate timelines—is dissipated in biology’s vigorous exchange of material and energy with the environment. The very nature of intelligence is to be selective; we would be paralyzed if we had to assay boundless infinitudes. Rather than holding open all possibilities, a mind must settle—at least tentatively—on one. The effort required to make that choice—and, from there, to act upon it—may be key to giving us at least the subjective feeling of free will.

So be careful what you wish for. In dark hours we may imagine alternate timelines and long for escape to another, but we seem to be inseparable from our own. Were it easier to flit between them, we might arrive only at oblivion. Like it or not, we’re stuck in this one—if we want to change it, we’ll have to do that the old-fashioned way.
Rights & Permissions


George Musser is a contributing editor at Scientific American and author of Putting Ourselves Back in the Equation (2023) and Spooky Action at a Distance (2015), both published by Farrar, Straus and Giroux. Follow him on Mastodon @gmusser@mastodon.social, Bluesky @gmusser.bsky.social and Threads @georgemusserjr@threads.net

#AmoPhysics, #NuclearPhysics,#AtomicNuclei#NuclearReactions#Radioactivity#NuclearFission#NuclearFusion#NuclearEnergy#NuclearPower#FusionResearch#FissionReactors#RadioactiveDecay#NuclearMedicine#NuclearAstrophysics, #ParticleAcceleration#NuclearSafety#NuclearEngineering#NuclearWeapons#RadiationProtection#NuclearPolicy#NuclearWasteManagement.


Visit: amo-physics-conferences.scifat.com/


Member Nomation link: https://x-i.me/amocon
Award Nomination link: https://x-i.me/amonom


For More Details : physics@scifat.com


Get Connected Here:
==================
Facebook : www.facebook.com/profile.php?id=100092029748922
Pinterest : in.pinterest.com/physicsresearch2000/
Youtube : www.youtube.com/channel/UCtntbI1RB0O0CFLpr575_fg
Instagram : www.instagram.com/amophysicsawards/

Friday, 6 December 2024

Molecular Blueprint Could Redesign Parkinson’s Disease Therapeutics




GPR6, a G protein-coupled receptor, is primarily expressed in the medium spiny neurons of the striatum, specifically within the striatopallidal pathway. This pathway is heavily impacted by the loss of dopamine-producing neurons in Parkinson’s disease (PD). Targeting GPR6 presents a promising therapeutic approach for a nondopaminergic treatment of PD, which would offer reduced risk for dyskinesia and other side effects. Now, a new preclinical study sheds light on the structure and function of GPR6. The insights could guide future research and the rational design of more selective GPR6-targeting drugs that are more effective and have fewer side effects for patients.

The findings are published in Science Signaling in an article titled, “Structural Insights into the High Basal Activity and Inverse Agonism of the Orphan Receptor GPR6 Implicated in Parkinson’s Disease.”


“GPR6 is an orphan G protein-coupled receptor with high constitutive activity found in D2-type dopamine receptor–expressing medium spiny neurons of the striatopallidal pathway, which is aberrantly hyperactivated in Parkinson’s disease,” the researchers wrote. “Here, we solved crystal structures of GPR6 without the addition of a ligand (a pseudo-apo state) and in complex with two inverse agonists, including CVN424, which improved motor symptoms in patients with Parkinson’s disease in clinical trials.”

Parkinson’s disease causes tremors, rigidity, and a loss of mobility over time, eventually leaving patients disabled. This immobility occurs due to the death of dopamine-releasing (or dopaminergic) neurons in the substantia nigra, a small but vital area of the brain that controls movement and cognition.

Treatments for Parkinson’s disease that restore dopamine levels can temporarily relieve symptoms, but there is currently no therapy that can halt the underlying degeneration of these neurons. However, there are some promising treatments in early trials that target GPR6, which is abundant in some dopaminergic neurons. This receptor has high basal activity—meaning it can exert biological effects even when not bound to an activating ligand. Moreover, it is found in the dopaminergic neurons that stop movement, which tend to be unusually active in Parkinson’s disease.


Mahta Barekatain, PhD, from the University of Southern California, and collaborators used mass spectrometry, mutagenesis, and computer models to analyze the structure of G protein-bound GPR6. The researchers discovered potential mechanisms behind the high basal activity and inverse agonism of GPR6.

They also solved the structures of G protein-bound GPR6 in complex with two compounds that suppress its basal activity (or inverse agonists), including one named CVN424. CVN424 is a non-dopamine therapy that inhibits GPR6, and has shown promise in clinical trials.

The structures and results from the new study could guide the rational design of drugs that modulate GPR6 signaling.

Thursday, 5 December 2024

New full Sun views show sunspots, fields and restless plasma


Zoom into Solar Orbiter's four new Sun images, assembled from high-resolution observations by the spacecraft's PHI and EUI instruments made on 22 March 2023. The PHI images are the highest-resolution full views of the Sun's visible surface to date, including maps of the Sun's messy magnetic field and movement on the surface. These can be compared to the new EUI image, which reveals the Sun's glowing outer atmosphere, or corona.

No object in the Solar System is as dynamic and multifaceted as the Sun. The ESA-led Solar Orbiter mission watches the Sun with no less than six imaging instruments. Together, these allow the spacecraft to peel away the Sun's many layers and reveal its many faces.

Today, the mission reveals the highest-resolution full views of the Sun’s visible surface (photosphere) to date. They are assembled from images made by the spacecraft's Polarimetric and Helioseismic Imager (PHI). This instrument not only takes images in visible light, but also measures the direction of the magnetic field, and maps how fast and in which direction different parts of the surface are moving.




PHI's measurements of the photosphere can be directly compared to a new image of the Sun's outer atmosphere (the corona) assembled from high-resolution images taken by the Extreme Ultraviolet Imager (EUI) instrument on the same day in March 2023. EUI images the Sun in ultraviolet light.

"The Sun's magnetic field is key to understanding the dynamic nature of our home star from the smallest to the largest scales. These new high-resolution maps from Solar Orbiter's PHI instrument show the beauty of the Sun's surface magnetic field and flows in great detail. At the same time, they are crucial for inferring the magnetic field in the Sun's hot corona, which our EUI instrument is imaging,” notes Daniel MΓΌller, Solar Orbiter's Project Scientist.




This release follows on from one two years ago, when the mission released full images of the Sun taken by the spacecraft's EUI and Spectral Imaging of the Coronal Environment (SPICE) instruments on 7 March 2022.

#AmoPhysics, #NuclearPhysics,#AtomicNuclei#NuclearReactions#Radioactivity#NuclearFission#NuclearFusion#NuclearEnergy#NuclearPower#FusionResearch#FissionReactors#RadioactiveDecay#NuclearMedicine#NuclearAstrophysics, #ParticleAcceleration#NuclearSafety#NuclearEngineering#NuclearWeapons#RadiationProtection#NuclearPolicy#NuclearWasteManagement.


Visit: amo-physics-conferences.scifat.com/


Member Nomation link: https://x-i.me/amocon
Award Nomination link: https://x-i.me/amonom


For More Details : physics@scifat.com


Get Connected Here:
==================
Facebook : www.facebook.com/profile.php?id=100092029748922
Pinterest : in.pinterest.com/physicsresearch2000/
Youtube : www.youtube.com/channel/UCtntbI1RB0O0CFLpr575_fg


Instagram : www.instagram.com/amophysicsawards/

Wednesday, 4 December 2024

Breakthroughs in Thermal Photonics Enable Efficient Subambient Daytime Radiative Cooling for Vertical Surfaces

KNOXVILLE, TN, December 03, 2024 /24-7PressRelease/ -- A groundbreaking study published in Science has achieved a significant advancement in thermal photonics, enabling efficient subambient daytime radiative cooling for vertical surfaces.

Radiative heat transfer is one of the most critical energy transfer mechanisms in nature. However, traditional blackbody radiation, due to its inherent characteristics such as non-directional, incoherent, broad-spectrum, and unpolarized nature, results in energy exchange between the radiating body and all surrounding objects, significantly limiting heat transfer efficiency and thermal flow control. These limitations hinder its practical applications.

A recent breakthrough study (DOI: 10.1126/science.adn2524) published in Science, uncovered by a research team led by Prof. Wei Li from the Changchun Institute of Optics, Fine Mechanics and Physics (CIOMP) of the Chinese Academy of Sciences, in collaboration with Prof. Shanhui Fan's team from Stanford University and Prof. Andrea Alu's team from the City University of New York, utilized thermal photonics to achieve cross-band synergistic control of thermal radiation in both angle and spectrum. They then designed a directional emitter with cross-scale symmetry-breaking, angularly asymmetric and spectrally selective thermal emission, achieving daytime subambient radiative cooling on vertical surfaces.

"Previous radiative coolers typically exhibited omnidirectional thermal radiation properties, making them suitable only for horizontal surfaces. However, when applied to vertical surfaces, the field of view to the cold sky is drastically reduced. At the same time, they must absorb considerable heat from the ground, surrounding objects, and atmosphere. This leads to the failure of subambient radiative cooling on vertical surfaces." said Professor Wei Li.

To address this challenge, they utilized thermal photonics to achieve cross-band synergistic control of thermal radiation in both angle and spectrum. They designed an angularly asymmetric and spectrally selective thermal emitter (AS emitter) using a cross-scale symmetry-breaking structure. The AS emitter consists of a sawtooth grating covered by an ultraviolet-visible reflective, IR transparent nanoporous polyethylene (nanoPE) film. The combination of the Ag layers and the nanoPE film results in strong reflection over the entire solar wavelength range. The SiN layers provide spectrally selective emissions due to its phonon polarization resonance and the outermost Ag layer is designed to reflect the thermal radiation of ground.

"Our AS emitter maintained a steady-state temperature substantially below the ambient temperature over the entire day. Even under peak sunlight, AS emitter still maintained a temperature of 2.5℃ below ambient temperature, corresponding to a temperature reduction of 4.3 and 8.9℃ compared to conventional high-performance radiative cooler and commercial white paint, respectively. Thanks to our design strategy's flexible ability to tune the angular coverage of thermal emission, we can redesign the AS emitter based on practical scenarios. Even if we face the AS emitter towards a hot building wall, it still can achieve subambient radiative cooling." said Fei Xie, the paper's first author and an assistant professor in Li's group.

Looking ahead, Prof. Wei Li envisions that their design strategy could also be applied to a wide range of common real-world scenarios involving inclined or vertical surfaces, such as walls, clothing, the sides of vehicles; and the capability of AS thermal emission has potential impacts of reduced heating and global energy consumption.

In conclusion, this innovative work breaks through the limitation of conventional radiative coolers, which can only function on horizontal surfaces, achieving a dimensional leap in radiative cooling technology from horizontal surfaces to practical three-dimensional scenarios. It also opens up new possibilities in the field of energy and sustainability, offering new thermal management solutions for energy-efficient technologies in a variety of applications.

References
DOI
10.1126/science.adn2524

Original Source URL
https://www.science.org/doi/10.1126/science.adn2524

Funding information
This work was supported by the National Natural Science Foundation of China (grants 62134009 and 62121005 to W.L.), the US Department of Energy (grant DE-FG02-07ER46426 to S.F.), and a Vannevar Bush Faculty Fellowship (to A.A.).

About Science
Science has been at the center of important scientific discovery since its founding in 1880—with seed money from Thomas Edison. Today, Science continues to publish the very best in research across the sciences, with articles that consistently rank among the most cited in the world.

Chuanlink Innovations, where revolutionary ideas meet their true potential. Our name, rooted in the essence of transmission and connection, reflects our commitment to fostering innovation and facilitating the journey of ideas from inception to realization.




#AmoPhysics, #NuclearPhysics,#AtomicNuclei, #NuclearReactions, #Radioactivity, #NuclearFission, #NuclearFusion, #NuclearEnergy, #NuclearPower, #FusionResearch, #FissionReactors, #RadioactiveDecay, #NuclearMedicine, #NuclearAstrophysics, #ParticleAcceleration, #NuclearSafety, #NuclearEngineering, #NuclearWeapons, #RadiationProtection, #NuclearPolicy, #NuclearWasteManagement.


Visit: amo-physics-conferences.scifat.com/


Member Nomation link: https://x-i.me/amocon
Award Nomination link: https://x-i.me/amonom


For More Details : physics@scifat.com


Get Connected Here:
==================
Facebook : www.facebook.com/profile.php?id=100092029748922
Pinterest : in.pinterest.com/physicsresearch2000/
Youtube : www.youtube.com/channel/UCtntbI1RB0O0CFLpr575_fg


Instagram : www.instagram.com/amophysicsawards/

Monday, 2 December 2024

Hexagon Fields Optical 3D Scanner With Zoom For Flexible Part Inspection




Hexagon's Manufacturing Intelligence division introduces the SmartScan VR800, an innovative high-productivity structured light scanner, marking a significant leap in optical 3D scanning technology.

The reengineered platform provides unparalleled flexibility, enabling users to customise data collection precisely. With three new software functions – Smart Resolution, Smart Zoom, and Smart Snap – users can efficiently manage inspection resolution and measurement volume without any mechanical changes to the system. The VR800 simplifies the scanning process by offering easy adjustment of scan detail and size through software, eliminating manual changes; fusion of detailed and broad scans into a single model for faster results and faster scan processing by reducing excess data while retaining essential details.

According to Pirmin Bitzi, General Manager for Portable Metrology Devices at Hexagon, the VR800 addresses this challenge by allowing efficient scanning at both high and low resolutions without manual adjustments. The scanner employs four 20 MP cameras in a dual stereo setup, combined with an optical-zoom digital projection unit. This unique combination enables measuring different volumes and varying resolution within each volume. The system's integrated controller unit ensures fast pre-processing of scan data on the device, delivering cleaner and easier-to-use data for metrology software.

The VR800's Smart Snap function significantly enhances workflow efficiency, especially on parts requiring high-resolution scans, streamlining the alignment process. These capabilities benefit a range of applications, including additive manufacturing, tool and die, and casting and moulding, providing flexibility in a continuous workflow.

Also Read:

Sumika Joins Hexagon To Reduce Plastic Carbon In New Vehicles

πŸ† Congratulations Dr. Nguyen Quang San! πŸŒŸπŸ”¬ Young Scientist Award | Global Physics Awards

πŸŽ‰ Heartiest Congratulations to Dr. Nguyen Quang San from Vietnam! πŸ‡»πŸ‡³πŸ† We are delighted to celebrate Dr. Nguyen Quang San for receiving...